Lightcone Podcast

Spenser Skates has spent more than a decade building Amplitude from a YC startup into a public company, and in that time, he's had to reinvent himself just as much as the product. Joining the Lightcone pod, he talks through the shift from founder to large-company CEO, the skepticism his team initially had toward AI, and the moment they realized the next wave of analytics would require a full reset. He walks through the hard reorgs, the bottom-up experiments, and the mindset changes that let Amplitude move fast again—and shares what it really takes for a big company to adapt when the ground under the industry moves.

Logistics is a multi-trillion-dollar industry that quietly powers the entire global economy — and it's shockingly manual. Ryan Petersen, founder & CEO of Flexport, joins the Lightcone to break down how AI is finally touching the physical world: making shipping cheaper, speeding up global trade, and automating work that used to live inside emails, spreadsheets, and phone calls.

MIT's new State of AI in Business report went viral for claiming that 95% of enterprise AI projects fail. But the real story isn't that AI doesn't work — it's just big companies can't build it. In this episode of the Lightcone, Garry, Harj, Diana, and Jared break down what the study really says, why in-house enterprise AI efforts keep stalling, and how startups are filling the gap with products that learn, integrate, and actually deliver value.

Nine out of ten people might tell you you're crazy. The tenth might see what you see. Garry, Harj, Jared, and Diana talk about contrarian bets — the ideas that look impossible until they work. From Uber and Coinbase to DoorDash and Flock Safety, they share how founders find opportunity where others see dead ends.

In the early days of a startup, speed is the best moat. But once you build something people want, how do you maintain your position and defend against the competition? In this episode of Lightcone, we dive into Hamilton Helmer’s Seven Powers framework to find out how these timeless business strategies hold up in today's world of AI startups.

Bob McGrew helped build some of the most influential technologies of the past two decades. Bob was an early engineer at PayPal, an early executive at Palantir and was recently Chief Research Officer at OpenAI - where he led the development of ChatGPT, GPT-4 and the o1 reasoning model. During his time at Palantir he was a pioneer of the Forward Deployed Engineer (FDE) model, a strategy that is at the heart of the AI boom today. On this episode of The Lightcone, he explains how FDEs became central to today's startups, why 'doing things that don't scale at scale' works, and where he sees the biggest opportunities for founders working in AI.

Tom Brown co-founded Anthropic after helping build GPT-3 at OpenAI. A self-taught engineer, he went from getting a B-minus in linear algebra to becoming one of the key people behind AI's scaling breakthroughs. And his work is paying off. Today, Anthropic's Claude is the go-to choice for developers, and his team is overseeing what he calls humanity's largest infrastructure buildout ever. On this episode of The Lightcone, he discusses his unconventional path from YC founder to AI researcher, the discovery of scaling laws that changed everything, and his advice for young engineers entering AI today.

AI has upended the once 'safe' CS career path. New grads are facing unemployment rates twice those of art history majors, and a CS degree is no longer a surefire ticket to wealth. At the same time, small, focused teams are scaling from zero to eight-figure revenue in months. In a special Lightcone Live at AI Startup School, Garry, Harj, Diana, and Jared discuss why it's now more important than ever to focus on building real skills, domain expertise, and agency rather than just chasing credentials.